{"id":2323,"date":"2022-05-18T12:19:25","date_gmt":"2022-05-18T04:19:25","guid":{"rendered":"https:\/\/linogreen.com\/?p=2323"},"modified":"2024-04-24T12:21:35","modified_gmt":"2024-04-24T04:21:35","slug":"the-fire-within-inflammation","status":"publish","type":"post","link":"https:\/\/linogreen.com\/en\/2022\/05\/18\/the-fire-within-inflammation\/","title":{"rendered":"The Fire Within \u2013 Inflammation"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2323\" class=\"elementor elementor-2323\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4d344ef elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4d344ef\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1632620\" data-id=\"1632620\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c06dd92 elementor-widget elementor-widget-text-editor\" data-id=\"c06dd92\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In general, inflammation refers to the body&#8217;s natural response to an offending agent, such as tissue damage or injury, or infection, which involves the recruitment of mononuclear leukocytes (monocyte and lymphocytes). Acute inflammation relatively occurs in short duration, lasting for a few hours or days, depending on the severity of the injury and generally a controlled inflammation that benefits the body by protecting against tissue damage or any harmful agent. In contrast to acute inflammation, chronic inflammation lasts for a prolonged period such as a few months, years and even a lifetime.<\/p><p><strong>What happens if inflammation left untreated?<\/strong><\/p><p>Chronic inflammation, if left untreated, would trigger your body to persistently produce inflammatory chemicals, causing long-term damage to healthy cells. Of grave concern is chronic inflammation has an established association with chronic diseases such as cardiovascular diseases and type 2 diabetes (figure 1).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fc283a2 elementor-widget elementor-widget-image\" data-id=\"fc283a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"345\" height=\"343\" src=\"https:\/\/linogreen.com\/wp-content\/uploads\/2022\/05\/linogreen-chronic-inflammation-figure.jpg\" class=\"attachment-large size-large wp-image-2350\" alt=\"\" srcset=\"https:\/\/linogreen.com\/wp-content\/uploads\/2022\/05\/linogreen-chronic-inflammation-figure.jpg 345w, https:\/\/linogreen.com\/wp-content\/uploads\/2022\/05\/linogreen-chronic-inflammation-figure-300x298.jpg 300w, https:\/\/linogreen.com\/wp-content\/uploads\/2022\/05\/linogreen-chronic-inflammation-figure-150x150.jpg 150w, https:\/\/linogreen.com\/wp-content\/uploads\/2022\/05\/linogreen-chronic-inflammation-figure-12x12.jpg 12w, https:\/\/linogreen.com\/wp-content\/uploads\/2022\/05\/linogreen-chronic-inflammation-figure-100x100.jpg 100w\" sizes=\"(max-width: 345px) 100vw, 345px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11c035e elementor-widget elementor-widget-text-editor\" data-id=\"11c035e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p align=\"center\">Figure 1: Consequences of chronic inflammation<\/p><p align=\"center\">Chronic diseases kill 41 million people yearly, accounting for 71% of global total mortality, according to the World Health Organization. Chronic diseases, also known as noncommunicable diseases, are distinguished by their long latency period and multifactorial nature, which includes genetic, behavioural, and environmental factors (table 1).<\/p><table border=\"1\" width=\"703\" cellspacing=\"0\" cellpadding=\"8\"><tbody><tr valign=\"TOP\"><td width=\"188\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Genetic <\/span><\/span><\/td><td width=\"238\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Behavioural <\/span><\/span><\/td><td width=\"227\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Environmental <\/span><\/span><\/td><\/tr><tr valign=\"TOP\"><td width=\"188\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Gene mutation <\/span><\/span><\/td><td width=\"238\"><p><span style=\"font-size: small;\"><span lang=\"en-MY\">Tobacco use, <\/span><\/span><\/p><p><span style=\"font-size: small;\"><span lang=\"en-MY\">exposure to secondhand smoke <\/span><\/span><\/p><\/td><td width=\"227\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Air pollution, water pollution <\/span><\/span><\/td><\/tr><tr valign=\"TOP\"><td width=\"188\">\u00a0<\/td><td width=\"238\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Unhealthy diet <\/span><\/span><\/td><td width=\"227\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Ultraviolet radiation <\/span><\/span><\/td><\/tr><tr valign=\"TOP\"><td width=\"188\">\u00a0<\/td><td width=\"238\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Physical inactivity<\/span><\/span><\/td><td width=\"227\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Endocrine-disrupting chemicals <\/span><\/span><\/td><\/tr><tr valign=\"TOP\"><td width=\"188\">\u00a0<\/td><td width=\"238\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Excessive alcohol consumption<\/span><\/span><\/td><td width=\"227\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Persistent organic pollutant<\/span><\/span><\/td><\/tr><\/tbody><\/table><p align=\"CENTER\"><span style=\"font-size: small;\"><span lang=\"en-MY\">Table 1: Factors of chronic diseases <\/span><\/span><\/p><p><b>How to measure it?<\/b><\/p><p>Chronic inflammation is a silent killer. It has no obvious symptoms or indications until it interferes with and damages healthy cells. Measuring inflammation is not as simple as measuring our weight on the scale. It is multifactorial, necessitating expert interpretation. A single test result should not be used to diagnose the inflammation condition. However, as a \u201cguide\u201d, inflammation can be measured by observing inflammatory markers* such as erythrocyte sedimentation rate (ESR), c-reactive protein (CRP) and plasma viscosity (PV) via a blood test. Always seek the advice of a professional when interpreting the results.<\/p><p>Erythrocyte Sedimentation Rate (ESR) test<\/p><ul><li><p align=\"JUSTIFY\">ESR test measures how quickly red blood cells fall or settle at the bottom of a test tube containing a blood sample. This process of \u201cfalling\u201d or \u201csettling\u201d is called sedimentation. The faster the sedimentation rate, the higher the levels of inflammation in the body.<\/p><\/li><li>Normal range**:<ul><li>Men: 0 \u2013 10 mm\/hr<\/li><li>Women: 0 \u2013 20 mm\/hr<\/li><\/ul><\/li><\/ul><p>C-reactive protein (CRP) test<\/p><ul><li>CRP is a protein synthesized by the liver and is released into the bloodstream in response to inflammation. A high level of CRP in the blood indicates there is inflammation or infection in your body.<\/li><li>Normal range**:<ul><li>10 mg\/L<\/li><\/ul><\/li><\/ul><p>Plasma Viscosity (PV) test<\/p><ul><li>Alongside ESR and CRP tests, PV can be used as a marker of inflammation. PV is used to access the viscosity or thickness of blood and indirectly measures the protein content in the plasma (liquid) part of the blood. A higher-than-normal PV value may associate with the inflammation state.<\/li><li><span lang=\"en-MY\"><span lang=\"en-MY\">Normal range**:<\/span><\/span><ul><li>1.50 \u2013 1.72 mPa.s<\/li><\/ul><\/li><\/ul><p><span style=\"font-size: small;\">*A number of conditions could affect the level of inflammation markers. Thus, its interpretation requires careful assessment by clinical practitioners and physicians.<br \/><\/span><span style=\"font-size: small;\">**These normal ranges may vary slightly difference between laboratories.<\/span><\/p><p><strong>Preventing inflammation<\/strong><\/p><p>While inflammation is necessary for the body&#8217;s defences, chronic inflammation may increase the risk of various diseases. The best advice to curb inflammation is to live a healthy lifestyle.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca004df elementor-widget elementor-widget-text-editor\" data-id=\"ca004df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>References<\/b><\/p><p>Brigden, M. (1999). Clinical utility of the erythrocyte sedimentation rate. American Family Physician, 60, 1443\u20131450.<\/p><p>Brigham and Women\u2019s Hospital. (n.d.). Environmental Risk Factors for Chronic Disease . Retrieved January 25, 2022, from <a href=\"https:\/\/www.brighamandwomens.org\/research\/departments\/channing-division-of-network-medicine\/environmental-risk-factors-for-chronic-disease\" target=\"_blank\" rel=\"noopener\">https:\/\/www.brighamandwomens.org\/research\/departments\/channing-division-of-network-medicine\/environmental-risk-factors-for-chronic-disease<\/a><\/p><p>CDC. (n.d.). About Chronic Diseases . Retrieved January 25, 2022, from <a href=\"https:\/\/www.cdc.gov\/chronicdisease\/about\/index.htm\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cdc.gov\/chronicdisease\/about\/index.htm<\/a><\/p><p>Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., Miller, A. H., Mantovani, A., Weyand, C. M., Barzilai, N., Goronzy, J. J., Rando, T. A., Effros, R. B., Lucia, A., Kleinstreuer, N., &amp; Slavich, G. M. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine 2019 25:12, 25(12), 1822\u20131832. <a href=\"https:\/\/doi.org\/10.1038\/s41591-019-0675-0\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41591-019-0675-0<\/a><\/p><p>Mayo Clinic. (2021, June 25). C-reactive protein test. Circulation; NLM (Medline). <a href=\"https:\/\/doi.org\/10.1161\/CIR.0000000000000678\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1161\/CIR.0000000000000678<\/a><\/p><p>Wehby, G. L., Domingue, B. W., &amp; Wolinsky, F. D. (2018). Genetic Risks for Chronic Conditions: Implications for Long-term Wellbeing. The Journals of Gerontology: Series A, 73(4), 477\u2013483. <a href=\"https:\/\/doi.org\/10.1093\/GERONA\/GLX154\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1093\/GERONA\/GLX154<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>In general, inflammation refers to the body&#8217;s natural response to an offending agent, such as tissue damage or injury, or infection, which involves the recruitment of mononuclear leukocytes (monocyte and lymphocytes). Acute inflammation relatively occurs in short duration, lasting for a few hours or days, depending on the severity of the injury and generally a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4113,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2323","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inflammation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Fire Within \u2013 Inflammation - Linogreen<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/linogreen.com\/en\/2022\/05\/18\/the-fire-within-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Fire Within \u2013 Inflammation - Linogreen\" \/>\n<meta property=\"og:description\" content=\"In general, inflammation refers to the body&#8217;s natural response to an offending agent, such as tissue damage or injury, or infection, which involves the recruitment of mononuclear leukocytes (monocyte and lymphocytes). 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